Dear Mr Lars,

It has come to our attention that you are experiencing troubling symptoms like leaving your fly open at the premier night of Symphony.

Please consider the AlzheimerAlert test. If you do not understand the information below, contact 911 immediately.

We would appreciate you passing this info on to your boomer friends at Unk's Troll-Free Saloon. They are reaching the time of greatest risk, especially if they fried their brains during times of youthful indiscretions and/or if they are obsessing on Leftist politics.

~~~~~~~~~~~~~~~

A free transport kit can be sent to you if you call 1-800-93-NYMOX (1-800-936-9669).

The AlzheimAlert test is available to physicians through Nymox Corporation¹s certified Clinical Reference Laboratory in Maywood, New Jersey at a cost of $295. The patient provides a first-morning urine sample for testing. The patient¹s doctor then forwards the sample to Nymox¹s laboratory where the test is performed. The results are then reported to the doctor, to be considered together with patient history, physical examination and other relevant medical data in arriving at a diagnosis. The test is not intended to replace a physician¹s diagnosis.

The AlzheimAlert test measures the level in urine of a brain protein called neural thread protein which is elevated early in Alzheimer¹s disease.

Neural thread protein, the brain protein detected by AlzheimAlert, has been repeatedly proven in independent, blind-coded clinical trials to be an accurate marker for Alzheimer¹s disease, both in confirming a diagnosis and in ruling out the disease. There is a wealth of published data on the test, the protein and its relationship to Alzheimer¹s disease, including, for example, such published studies and reports as:

… Journal of Clinical Investigation (1997; 100: 3093-3104), … Journal of Contemporary Neurology (1998; art. 4a),

… Journal of Clinical Laboratory Analysis (1998; 12: 285-288) and (1998; 12: 223-226),

… Alzheimer¹s Reports (1999; 2: 327-332), (2000; 3: 177-184) and (2001, 4: 61-65), … Neurology (2000; 54: 1498-1504) and (2000; 55: 1068), … Journal of Alzheimer¹s Disease (2001; 3: 345-353),

… Journal of Neuropathology and Experimental Neurology (1996; 55: 1038-1050),

… Cellular and Molecular Life Sciences (2001; 58: 844-849), and … Neurology and Clinical Neurophysiology (2001), in press.

Reports about this Nymox technology have also been featured in prestigious trade and lay publications such as Clinica (Sept.25, 2000), Genetic Engineering News (Oct.1, 2000), Clinical Laboratory News (September, 1999 and October, 2000), Modern Maturity (Dec., 2000), ADVANCE for Administrators of the Laboratory (June, 2001), ASRT Scanner (August, 2001), RN magazine (August, 2001), Clinical Geriatrics (November 2000), LabMedica International (June 1998), and Clinical Laboratory International (October 1998). The NTP test is also featured on The National Institute on Aging ­ National Institute of Mental Health website (Progress Report on Alzheimer¹s Disease).

The early diagnosis of Alzheimer¹s disease is important to physicians, patients and their families. It enables them to make informed and early social, legal and medical decisions about treatment and care. It permits patients to take advantage of new improvements in drug treatment and care. Even a modest delay in institutionalization can mean substantial social and financial savings.

There is a widely recognized need for a simple, accurate and convenient test that can help physicians diagnose Alzheimer¹s disease. The U.S. Surgeon General has described the diagnosis of Alzheimer¹s disease as "challenging" and its early detection as "difficult" and noted that, as a result, Alzheimer¹s disease and other dementias are "currently underrecognized, especially in primary care settings, where most older patients seek care."

The AlzheimAlert test meets all the standards for a diagnostic aid for Alzheimer¹s disease. It is a convenient and easy to administer urine test. It is cost-effective. It helps in the early detection of the disease. It measures a disease marker ­ neural thread protein ­ that is strongly associated with the underlying disease process.

REFERENCES

1. de la Monte, S. M., Wands, J. R. The AD7c-NTP neuronal thread protein biomarker for detecting Alzheimer¹s disease. J. Alz. Dis. 2001; 3: 345-353.

2. Munzar, M., Levy, S., Rush, R. et al. Competitive ELISA format urinary assay of neural thread protein in Alzheimer¹s disease. Alzheimer¹s Reports, 2001; 4 (2): 61-65.

3. Fitzpatrick, J., Munzar, M., Focht, M., Bibiano, R., Averback, P. 7C Gold urinary assay of neural thread protein in Alzheimer¹s disease. Alzheimer¹s Reports, 2000; 3 (3): 155-159.

4. Munzar, M., Levy, S., Rush, R. et al. Clinical study of a competitive ELISA format urinary assay for neural thread protein in Alzheimer¹s disease. Neurology & Clinical Neurophysiology 2001, in press.

5. de la Monte, S.M., Ghanbari, H., Ghanbari, K., Averback, P., Wands, J.R. AD7C-NTP biomarker for Alzheimer¹s disease. Alzheimer¹s Reports, 2000; 2 (6): 327-332.

6. Kahle, P.J., Jakowec, M., Teipel, S.J. et al. Combined assessment of Tau and neuronal thread protein in Alzheimer¹s disease CSF. Neurology, 2000; 54: 1498-1504.

7. de la Monte, S.M., Ghanbari, K., Frey, W.H., Beheshti, I., Averback, P., Hauser, S.L., Ghanbari, H.A., Wands, J.R. Characterization of the AD7C-NTP cDNA expression in Alzheimer¹s disease and measurement of a 41-kD protein in cerebrospinal fluid. J. Clin. Invest., 1997; 100: 3093-3104.

8. Ghanbari, H., Ghanbari, K., Munzar, M., Averback, P. Specificity of AD7C-NTP as a Biochemical Marker for Alzheimer¹s Disease. J. Contemp. Neurol., 1998; 4: 2-6.

9. Ghanbari, H., Ghanbari, K., Beheshti, I., Munzar, M., Vasauskas, A., Averback, P. Biochemical Assay for AD7C-NTP in Urine as an Alzheimer¹s Disease Marker. J. Clin. Lab. Anal., 1998; 12: 285-288.

10. de la Monte, S.M., Carlson, R.I., Brown, N.V., Wands, J.R. Profiles of neuronal thread protein expression in Alzheimer¹s disease. J. Neuropath. Exp. Neurol., 1996; 55: 1038-1050.

11. de la Monte, S.M., Xu, Y.Y., Hutchins, G.M., Wands, J.R., Developmental patterns of neuronal thread protein gene expression in Down syndrome. J. Neurol. Sci., 1996; 135: 118-25.

12. de la Monte, S.M., Volicer, L., Hauser, S.L., Wands, J.R. Increased levels of neuronal thread protein in cerebrospinal fluid of patients with Alzheimer¹s disease. Ann. Neurol., 1992; 32: 733-42.

13. de la Monte, S.M., Wands, J.R. Neuronal thread protein over-expression in brains with Alzheimer¹s disease lesions. J. Neurol. Sci., 1992; 113: 152-64.

14. de la Monte, S.M., Ozturk, M., Wands, J.R., Enhanced expression of an exocrine pancreatic protein in Alzheimer¹s disease and the developing human brain. J. Clin. Invest., 1990; 86: 1004-13.

15. Ozturk, M., de la Monte, S.M., Gross, J., Wands, J.R. Elevated levels of an exocrine pancreatic secretory protein in Alzheimer¹s disease brain. Proc. Natl. Acad. Sci. USA, 1989; 86: 419-23.

16. Kahle, P., Murphy, G., Yesavage, J.A. et al. Soc. Neurosci. Abstr., 24, 1, 1222. October 1998.

17. Ghanbari, H., Munzar, M., Ghanbari, K. et al. Soc. Neurosci. Abstr., 24, 2, 1270. October 1998.

18. Ghanbari, H., Munzar, M., et al. American Psychiatric Association Institute on Psychiatric Services. Los Angeles, October 3, 1998.

19. Beheshti, I., Ghanbari, H., Ghanbari, K. et al. American Association for Clinical Chemistry. Chicago, August 6, 1998.

20. Kahle, P., et al. 6th International Conference on AD & Related Disorders. Amsterdam, July

21. Ghanbari, H., Munzar, M., Ghanbari, K. et al. 6th International Conference on AD & Related Disorders, July 20, 1998.

22. Ghanbari, H., Munzar, M., Ghanbari, K., et al. American Psychiatric Association, NR 347. Toronto, June 2, 1998.

23. Ghanbari, H., Averback, P., Ghanbari, K. et al. American Geriatric Society. Seattle, May 9, 1998.

24. Averback, P., Ghanbari, H., Munzar, M. et al., American Association for Geriatric Psychiatry. San Diego, March 1998.

25. Ghanbari, H., Frey, W., Ghanbari, K. et al. 5th International Conference of AD & Related Disorders. Osaka, July 29, 1996.

26. Munzar, M., Rush, R., Levy, S. et al. World Congress of Neurology, 1520, London, June 19, 2001.

27. de la Monte, S.M., Wands, J.R. Alzheimer-Associated Neuronal Thread Protein-Induced Apoptosis and Impaired Mitochondrial Function in Human Central Nervous System-Derived Neuronal Cells. J. Neuropathol. Exp. Neurol., 2001; 60 (2): 195-207.

28. de la Monte, S.M., Xu, Y.Y., Wands, J.R. Modulation of neuronal thread protein expression with neuritic sprouting: relevance to Alzheimer¹s disease. J. Neurol. Sci., 1996; 138: 26-35.

29. Xu, Y.Y., Bhavani, K., Wands, J.R., de la Monte, S.M. Ethanol inhibits insulin receptor substrate-1 tyrosine phosphorylation and insulin-stimulated neuronal thread protein gene expression. Biochem. J., 1995; 310: 125-32.

30. Xu, Y.Y., Bhavani, K., Wands, J.R., de la Monte, S.M. Insulin-induced differentiation and modulation of neuronal thread protein expression in primitive neuroectodermal tumor cells is linked to phosphorylation of insulin receptor substrate-1. J. Mol. Neurosci., 1995; 6: 91-108.

31. Xu, Y.Y., Wands, J.R., de la Monte, S.M. Characterization of thread proteins expressed in neuroectodermal tumors. Cancer Res., 1993; 53: 3823-9.

32. Ghanbari, K., Ghanbari, H. A Sandwich Enzyme Immunoassay for Measuring AD7C-NTP as an Alzheimer¹s Disease Marker: AD7C Test. J. Clin. Lab. Anal., 1998; 12: 223-226.

33. Chong, J.K., Cantrell, L., Husain, M., Riesing, S., Miller, B.E., Wands, J., de la Monte, S.M., Ghanbari, H.A. Automated microparticle enzyme immunoassay for neural thread protein in cerebrospinal fluid from Alzheimer¹s disease patients. J. Clin. Lab. Anal., 1992; 6: 379-83.

34. Wallach, J. Interpretation of Diagnostic Tests, 5th Ed. Little, Brown, Boston. 1992: 85.

35. Chui, H.C., Tierney, M., Zarow, C., Lewis, A., Sobel, E., Perlmutter, L.S. Neuropathologic Diagnosis of Alzheimer Disease: Interrater Reliability in the Assessment of Senile Plaques and Neurofibrillary Tangles. Alzheimer Disease and Associated Disorders, 1993; 7 (1): 48-54.

36. Jost, B.C., Grossberg, G.T. The natural history of Alzheimer¹s disease: a brain bank study. J. Am. Geriatr. Soc., 1995; 43: 1248-55.

-- (lars@indy.net), January 04, 2002

Answers

Lars, you sent us an empty bottle.

-- (Nymox Corp@Maywood.NJ), January 04, 2002.

Mr Lars should try pissing up a rope.

-- (Dumbya@Dumptruck.TX), January 05, 2002.